2-Methoxyethanol → HCID 178496180、化合物

HRID 2042820ノート

反応式

HRID 2042820 の反応式
[CH3:1][O:2][CH2:3][CH2:4][OH:5].CC([O-])(C)C.[K+].Cl[C:13]1[N:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:14]=1[C:15]([NH:17][C@H:18]1[CH2:23][CH2:22][C@H:21]([C:24]([F:27])([F:26])[F:25])[CH2:20][CH2:19]1)=[O:16]>C1COCC1.O>[Cl:32][C:30]1[CH:29]=[CH:28][C:14]([C:15]([NH:17][C@H:18]2[CH2:23][CH2:22][C@H:21]([C:24]([F:27])([F:26])[F:25])[CH2:20][CH2:19]2)=[O:16])=[C:13]([O:5][CH2:4][CH2:3][O:2][CH3:1])[N:31]=1

参加物

6

反応物 3

HCID 80192-MethoxyethanolHCID 23665647Potassium tert-butoxideHCID 178523747HCID 178523747、化合物

生成物 1

HCID 178496180HCID 178496180、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2-Methoxyethanol (550 μL, 6.94 mmol) is added at rt to KOtBu (750 mg, 6.35 mmol) in THF (30 mL) and it is stirred for 5 min. 2,6-Dichloro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (2.00 g, 5.86 mmol) is added to the reaction mixture and it is stirred for 10 min at rt. The reaction mixture is diluted with water, filtered and the filtrate is concentrated. The residue is treated with water, filtered off, washed with water and dried.

後処理

  1. stirringis stirred for 10 min at rt
  2. filtrationfiltered
  3. concentrationthe filtrate is concentrated
  4. additionThe residue is treated with water
  5. filtrationfiltered off
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-043e2677ff7045c3a922bf56bde1255e
出典データセット
uspto-grants-2013_11
特許番号
US08586604B2

反応ノート

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