Sodium Hydroxide → HCID 86680888、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@H:13]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C@@H:12]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C@H:11]([O:30][CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C@@H:10]([CH2:38][O:39][CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[O:9]2)=[CH:4][C:3]=1[C:47]1([C:50]#N)[CH2:49][CH2:48]1.[OH-:52].[Na+].CCO.[OH2:57]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@H:13]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C@@H:12]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C@H:11]([O:30][CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C@@H:10]([CH2:38][O:39][CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[O:9]2)=[CH:4][C:3]=1[C:47]1([C:50]([OH:57])=[O:52])[CH2:49][CH2:48]1参加物
4
反応条件
- 温度
- 110 °C
実験手順
To a solution of cyanide 42 (3.0 g, 4.25 mmol) in EtOH/H2O (20 mL/20 mL) was added NaOH (20.5 g, 423 mmol). The mixture was stirred at 110° C. for 15 hours. The mixture was cooled to room temperature and evaporated in vacuo to remove EtOH. The residue was diluted with H2O, cooled to 0° C. and acidified with c-HCl solution. The titled compound 43 was precipitated as a solid, dissolved with EtOAc and extracted. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo to provide the titled compound 43 (2.89 g, 99%).