Dimethylformamide → [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

HRID 2043

反応式

HRID 2043 の反応式
[Na].[N:2]1([C:13](=[O:14])[C:12]2[NH:11][CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5])[CH3:3].Cl[CH2:16][P:17](=[O:20])(C)[CH3:18].[CH3:21]N(C=O)C>>[CH3:7][N:6]1[C:8]2[N:9]=[CH:10][N:11]([CH3:21])[C:12]=2[C:13](=[O:14])[N:2]([CH2:3][P:17](=[O:20])([CH3:18])[CH3:16])[C:4]1=[O:5]

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 74224Phosphine oxide, (chloromethyl)dimethyl-HCID 669736033,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, sodium salt

生成物 1

HCID 19689229[1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

実験手順

A solution of 20.2 g (0.1 mol) of theophylline sodium salt in 400 ml of DMF was heated at 130° C. for 3 hours with 12.7 g of chloromethyldimethyl-phosphine oxide. The solution was filtered, the solvent was evaporated and the residue was taken up in methanol. The precipitate was filtered off and dried to constant weight under reduced pressure.

後処理

  1. filtrationThe solution was filtered
  2. customthe solvent was evaporated
  3. filtrationThe precipitate was filtered off
  4. customdried to constant weight under reduced pressure

出典と根拠

ORDレコード
ord-3604df54e33345c3b923bde3a99dbbb6
出典データセット
uspto-grants-1998_03
特許番号
US05728686

関連ノート

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