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Dimethylformamide → [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Phosphine oxide, (chloromethyl)dimethyl- | HCID 74224 | — |
| 反応物 | 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, sodium salt | HCID 66973603 | — |
| 生成物 | [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide | HCID 19689229 | — |
反応手順
A solution of 20.2 g (0.1 mol) of theophylline sodium salt in 400 ml of DMF was heated at 130° C. for 3 hours with 12.7 g of chloromethyldimethyl-phosphine oxide. The solution was filtered, the solvent was evaporated and the residue was taken up in methanol. The precipitate was filtered off and dried to constant weight under reduced pressure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728686 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-3604df54e33345c3b923bde3a99dbbb6 |
| 出典メモ | uspto-grants-1998_03 |