反应详情

A solution of 20.2 g (0.1 mol) of theophylline sodium salt in 400 ml of DMF was heated at 130° C. for 3 hours with 12.7 g of chloromethyldimethyl-phosphine oxide. The solution was filtered, the solvent was evaporated and the residue was taken up in methanol. The precipitate was filtered off and dried to constant weight under reduced pressure.

1. filtrationThe solution was filtered
2. customthe solvent was evaporated
3. filtrationThe precipitate was filtered off
4. customdried to constant weight under reduced pressure