Cesium carbonate → 1-Bromo-3-fluoro-5-propoxybenzene
反応式
[CH2:1](I)[CH2:2][CH3:3].[Br:5][C:6]1[CH:7]=[C:8]([OH:13])[CH:9]=[C:10]([F:12])[CH:11]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[Br:5][C:6]1[CH:7]=[C:8]([O:13][CH2:1][CH2:2][CH3:3])[CH:9]=[C:10]([F:12])[CH:11]=1参加物
5
実験手順
Add propyl iodide (5.74 g, 33.77 mmol) to 3-bromo-5-fluoro-phenol (4.30 g, 22.51 mmol) and cesium carbonate (11.00 g, 33.77 mmol) in N,N-dimethylformamide (75 mL) and stir at room temperature 1 hour, then heat at 50° C. for 1 hour. Cool to room temperature and dilute with hexanes. Wash (water, 1N lithium chloride, saturated aqueous sodium chloride), dry (magnesium sulfate), filter and concentrate to give the desired compound as a colorless oil, 4.40 g (83.8%).
後処理
- temperatureheat at 50° C. for 1 hour
- temperatureCool to room temperature
- washWash (water, 1N lithium chloride, saturated aqueous sodium chloride)
- dry with materialdry (magnesium sulfate)
- filtrationfilter
- concentrationconcentrate
出典と根拠
- ORDレコード
- ord-eb96c5088f05479f886160d7fefef98d
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745438B2
反応ノート
読み込み中…