Sodium Hydroxide → HCID 67462546、化合物
反応式
[CH3:1][C:2]1[N:6]([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3N=[C:19]([C:21]([O:23]CC)=[O:22])[CH:18]=[N:17]3)[CH2:12][CH2:11]2)=[O:9])[N:5]=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.[CH3:30]N([C@H]1C2C(=CC=CC=2)CCC1)C(C1C=NN(C2CCN(C(=O)CN3C(C)=CC(C(F)(F)F)=N3)CC2)C=1)=O.[OH-].[Na+]>>[CH3:1][C:2]1[N:6]([CH2:7][C:8]([N:10]2[CH2:11][CH2:12][CH:13]([N:16]3[CH:30]=[C:19]([C:21]([OH:23])=[O:22])[CH:18]=[N:17]3)[CH2:14][CH2:15]2)=[O:9])[N:5]=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1参加物
4
実験手順
By a procedure analogous to that of Example 32 Step C, ethyl 2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-2H-1,2,3-triazole-4-carboxylate (0.24 g, 0.58 mmol) (i.e. the product of Example 33, Step B) was hydrolyzed with 1 N aqueous sodium hydroxide (1.2 mL, 1.2 mmol) to afford 0.125 g of the title compound as a white solid.
出典と根拠
- ORDレコード
- ord-6dd1c28dba7344818bbc79db281af44b
- 出典データセット
- uspto-grants-2013_11