HCID 67440464、化合物 → HCID 67442053、化合物

HRID 2045644ノート

反応式

HRID 2045644 の反応式
[CH:1]([NH:4][S:5]([C:8]1[CH:9]=[C:10]([C:14]2[C:23]([CH3:25])([CH3:24])[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:26]([O:28][CH3:29])=[O:27])[CH:20]=3)[N:15]=2)[CH:11]=[CH:12][CH:13]=1)(=[O:7])=[O:6])([CH3:3])[CH3:2]>CO.[Pd]>[CH:1]([NH:4][S:5]([C:8]1[CH:9]=[C:10]([CH:14]2[C:23]([CH3:25])([CH3:24])[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:26]([O:28][CH3:29])=[O:27])[CH:20]=3)[NH:15]2)[CH:11]=[CH:12][CH:13]=1)(=[O:7])=[O:6])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 67440464HCID 67440464、化合物

生成物 1

HCID 67442053HCID 67442053、化合物収率 48.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a stirred solution of methyl 2-(3-(N-isopropylsulfamoyl)phenyl)-3,3-dimethyl-3,4-dihydroquinoline-6-carboxylate (245 mg, 0.59 mmol) in methanol (5 mL) was added 10% Pd/C (130 mg). The mixture was hydrogenated by a H2 balloon. After filtration, the filtrated was concentrated and purified on preparative Thin layer chromatography to afford 120 mg of methyl 2-(3-(N-isopropylsulfamoyl)phenyl)-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxylate as syrup. (Yield: 28%, three steps.)

後処理

  1. filtrationAfter filtration
  2. concentrationthe filtrated was concentrated
  3. custompurified on preparative Thin layer chromatography

出典と根拠

ORDレコード
ord-ed572cfcc80d4794b8902f7d01457317
出典データセット
uspto-grants-2013_11
特許番号
US08586747B2

反応ノート

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