Hydrochloric Acid → HCID 2959448、化合物

HRID 2045799ノート

反応式

HRID 2045799 の反応式
[C:1]([CH:3]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])#[N:2].[ClH:16]>C(O)C.[Pd]>[ClH:16].[NH2:2][CH2:1][CH:3]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 12414061Ethyl 3-cyano-3-phenylpropanoate

生成物 1

HCID 2959448HCID 2959448、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 3-cyano-3-phenylpropanoate 2 (9.27 g, 45.6 mmol) in ethanol (70 mL) was added concentrated hydrochloric acid (2.4 mL) followed by 10% palladium on carbon (1.0 g) and the reaction hydrogenated at 80 psi for 18 h. The mixture was filtered through celite and concentrated in vacuo. The residue was triturated in ether and filtered to give 2 (4.97 g in 2 crops, 45%) as a white solid.

後処理

  1. customthe reaction hydrogenated at 80 psi for 18 h
  2. filtrationThe mixture was filtered through celite and
  3. concentrationconcentrated in vacuo
  4. customThe residue was triturated in ether
  5. filtrationfiltered
  6. customto give 2 (4.97 g in 2 crops, 45%) as a white solid

出典と根拠

ORDレコード
ord-a1262f8e117d4da398c21aec6611a8b4
出典データセット
uspto-grants-2013_11
特許番号
US08592395B2

反応ノート

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