Methyl 3-ethylbenzoate → (3-Ethylphenyl)methanol

HRID 2045838

反応式

HRID 2045838 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12](OC)=[O:13])[CH3:8]>C1COCC1>[CH2:7]([C:9]1[CH:10]=[C:11]([CH2:12][OH:13])[CH:16]=[CH:17][CH:18]=1)[CH3:8]

参加物

4

反応物 2

HCID 12430992Methyl 3-ethylbenzoateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 104659(3-Ethylphenyl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Lithium aluminum hydride (3.1 mL of 1.0 M solution in THF, 3.1 mmol) was added to a solution of methyl 3-ethylbenzoate (500 mg, 3.05 mmol) in THF (12 mL) at 0° C. After 2 h at 0° C., the reaction was quenched by the addition of saturated aqueous Rochelle's salt (50 mL) and stirred vigorously overnight at room temperature. The reaction mixture was extracted with Et2O (3×100 mL). The combined organic phase was dried (Na2SO4), filtered and concentrated in vacuo to afford (3-ethylphenyl)methanol which was shown to be ˜90% pure by 1H NMR analysis and was taken on without further purification.

後処理

  1. customthe reaction was quenched by the addition of saturated aqueous Rochelle's salt (50 mL)
  2. extractionThe reaction mixture was extracted with Et2O (3×100 mL)
  3. dry with materialThe combined organic phase was dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e615c22f6a3f46d3b3c09d9f79bfbbb8
出典データセット
uspto-grants-2013_11
特許番号
US08592413B2

関連ノート

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