Methyl 3-ethylbenzoate → (3-Ethylphenyl)methanol
反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12](OC)=[O:13])[CH3:8]>C1COCC1>[CH2:7]([C:9]1[CH:10]=[C:11]([CH2:12][OH:13])[CH:16]=[CH:17][CH:18]=1)[CH3:8]参加物
4
実験手順
Lithium aluminum hydride (3.1 mL of 1.0 M solution in THF, 3.1 mmol) was added to a solution of methyl 3-ethylbenzoate (500 mg, 3.05 mmol) in THF (12 mL) at 0° C. After 2 h at 0° C., the reaction was quenched by the addition of saturated aqueous Rochelle's salt (50 mL) and stirred vigorously overnight at room temperature. The reaction mixture was extracted with Et2O (3×100 mL). The combined organic phase was dried (Na2SO4), filtered and concentrated in vacuo to afford (3-ethylphenyl)methanol which was shown to be ˜90% pure by 1H NMR analysis and was taken on without further purification.
後処理
- customthe reaction was quenched by the addition of saturated aqueous Rochelle's salt (50 mL)
- extractionThe reaction mixture was extracted with Et2O (3×100 mL)
- dry with materialThe combined organic phase was dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-e615c22f6a3f46d3b3c09d9f79bfbbb8
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08592413B2
反応ノート
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