Trifluoroacetic acid → HCID 86660884、化合物
反応式
C(OC(=O)[NH:7][C@@H:8]1[C@@H:13]([NH2:14])[CH2:12][CH2:11][CH2:10][C:9]1([F:16])[F:15])(C)(C)C.[C:18]([OH:24])([C:20]([F:23])([F:22])[F:21])=[O:19]>ClCCl>[F:21][C:20]([F:23])([F:22])[C:18]([O-:24])=[O:19].[F:21][C:20]([F:23])([F:22])[C:18]([O-:24])=[O:19].[F:15][C:9]1([F:16])[CH2:10][CH2:11][CH2:12][C@H:13]([NH3+:14])[C@H:8]1[NH3+:7]参加物
4
実験手順
A mixture of tert-butyl[(1R,6S)-6-amino-2,2-difluorocyclohexyl]carbamate (5 g, 19.98 mmol) and TFA (6.16 mL, 80 mmol) in dichloromethane (50 mL) was left to stir overnight, and concentrated to afford the title compound as a brown oil. 19F NMR (CDCl3, 564 MHz) −81.07 (s, 6F); −99.7-−100.1 (d, 1F); −111.1-−111.5 (d, 1F).
後処理
- waitwas left
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a501024bbe3f45b3af43f245bd97e343
- 出典データセット
- uspto-grants-2013_11
- 特許番号
- US08592425B2
反応ノート
読み込み中…