Sodium borohydride → 1-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-ol

関与物質

反応手順

To a suspension of 1-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-one (0.05 g, 0.17 mmol) in methanol (50 mL) was added sodium borohydride (NaBH4) (0.01 g, 0.17 mmol) and the resulting mixture was stirred for 1 h at room temperature and then quenched with few drops of water. The solvent was removed under reduced pressure, the crude dissolved in EtOAc (5 mL) and filtered, then the organic phase was evaporated under reduced pressure to afford 0.02 g (36%) of the title compound.

情報源と証拠