Hydrazine hydrate (1:1) → 1H-pyrrole-2-carbohydrazonamide

HRID 2048131ノート

反応式

HRID 2048131 の反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].O.[NH2:12][NH2:13]>C(O)C.O>[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:12][NH2:13])[NH2:7]

参加物

6

反応物 3

HCID 24654Hydrazine hydrate (1:1)HCID 138277Pyrrole-2-carbonitrileHCID 10942334Sodium Methoxide

生成物 1

HCID 1363872481H-pyrrole-2-carbohydrazonamide

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of 1H-pyrrole-2-carbonitrile 10 g (108 mM) and sodium methoxide (1 eq) in ethanol (20 ml) and stirred for 10 min. Hydrazine hydrate (3 eq.) is then added and resulting reaction mixture is stirred at room temperature for 18 hrs. Reaction mass is then diluted with water, extracted with ethyl acetate, dried over anhydrous sodium sulphate and concentrated under vacuum to yield desired compound.

後処理

  1. customresulting
  2. customreaction mixture
  3. customReaction mass
  4. extractionextracted with ethyl acetate
  5. dry with materialdried over anhydrous sodium sulphate
  6. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-b2f4fdbed86e461184fdb9e306592e34
出典データセット
uspto-grants-2013_11
特許番号
US08592591B2

反応ノート

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