Ethanone, 2-chloro-1,2-diphenyl- → Thiazole, triphenyl-

HRID 2049272

反応式

HRID 2049272 の反応式
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]1([C:16]([CH:18](Cl)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(O)(C)C>[C:10]1([C:16]2[S:8][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:9][C:18]=2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 95343Ethanone, 2-chloro-1,2-diphenyl-HCID 683563Thiobenzamide

生成物 1

HCID 1712256Thiazole, triphenyl-

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Thiobenzamide (13.7 g, 0.10 mole) and desyl chloride (23.1 g, 0.10 mole) are heated under reflux in isopropyl alcohol (100 ml) for three hours. When the reaction mixture is cooled, the white solid precipitate formed is filtered off, washed twice with isopropyl alcohol, and dried. The yield of triphenylthiazole, m.p. 84°-85.5° C., is 21.5 g or 69%.

後処理

  1. temperatureWhen the reaction mixture is cooled
  2. customthe white solid precipitate formed
  3. filtrationis filtered off
  4. washwashed twice with isopropyl alcohol
  5. customdried

出典と根拠

ORDレコード
ord-3912ad2349f94687be5fa180fdf6869a
出典データセット
uspto-grants-1980_04
特許番号
US04197306

関連ノート

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