Tributylstannane → HCID 23466037、化合物

HRID 2049694ノート

反応式

HRID 2049694 の反応式
[OH:1][C:2]1([CH3:18])[CH:8](Br)[CH:7]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:6][C:4](=[O:5])[CH2:3]1.C([SnH](CCCC)CCCC)CCC>O1CCCC1>[OH:1][C:2]1([CH3:18])[CH2:8][CH:7]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:6][C:4](=[O:5])[CH2:3]1

参加物

4

反応物 2

HCID 5948TributylstannaneHCID 12878303HCID 12878303、化合物

生成物 1

HCID 23466037HCID 23466037、化合物収率 54.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 200 mg of 3-hydroxy-3-methyl-4-bromo-7-phenyl-5-heptanolide in 2 ml of anhydrous tetrahydrofuran was added 500 mg of tri-n-butyltin hydride and the mixtue was allowed to stand overnight at room temperature. After completion of the reaction, tetrahydrofuran was evaporated and n-hexane was added to the residue to precipitate an oily substance, which was pruified by a thin layer chromatography (silica gel) affording 82 mg of the desired compound.

後処理

  1. customwas evaporated
  2. additionn-hexane was added to the residue
  3. customto precipitate an oily substance, which

出典と根拠

ORDレコード
ord-97b6bacbbf0140e49a74d45d903393da
出典データセット
uspto-grants-1980_04
特許番号
US04198425

反応ノート

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