Water → 1-(1-Phenylpenta-1,4-dien-1-yl)pyrrolidine

HRID 2049759

反応式

HRID 2049759 の反応式
[C:1]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=O)[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1.B(F)(F)F.CCOCC.O>C1(C)C=CC=CC=1>[C:7]1([C:1]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:2][CH2:3][CH:4]=[CH2:5])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

6

反応物 4

HCID 962WaterHCID 8000Boron trifluoride etherateHCID 31268PyrrolidineHCID 1013624-Penten-1-one, 1-phenyl-

生成物 1

HCID 543330581-(1-Phenylpenta-1,4-dien-1-yl)pyrrolidine収率 79%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

In 50 ml of toluene, 1.60 g of 4-pentenophenone, 2.13 g of pyrrolidine and 0.14 g of boron trifluoride etherate were dissolved. The mixture was refluxed for 46 hours using a Cope water separator and molecular sieve 4A as the dehydrating agent. After having distilled out the solvent under a reduced pressure, the residue was subjected to a distillation under a reduced pressure to obtain 1.68 g of the desired enamine (yield: 79%).

後処理

  1. temperatureThe mixture was refluxed for 46 hours
  2. distillationAfter having distilled out the solvent under a reduced pressure
  3. distillationthe residue was subjected to a distillation under a reduced pressure

出典と根拠

ORDレコード
ord-d47b98a8d5df45cdb9a5d6ee020f46e3
出典データセット
uspto-grants-1980_04
特許番号
US04198510

関連ノート

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