Hydrochloric Acid → Hydroxyphenylacetic acid

HRID 2049809

反応式

HRID 2049809 の反応式
O.[OH:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7](O)[C:8]([O-:10])=[O:9])=[CH:5][CH:4]=1.[Na+].[PH2]([O-])=O.[K+].[PH2](O)=O.Cl>O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 4124402Phosphinic AcidHCID 236981332-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrateHCID 178527018HCID 178527018、化合物

生成物 1

HCID 127Hydroxyphenylacetic acid収率 67%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
143 °C

実験手順

A stirred mixture of sodium p-hydroxymandelate monohydrate (21.2 g.), potassium hypophosphite (52 g.), 50% w/v aqueous hypophosphorous acid (2.2. ml.) and water (10 ml.) is heated under reflux for 22 hours (internal temperature 143° C.) and then cooled. The mixture is diluted with water, acidified with hydrochloric acid and extracted with methyl isobutyl ketone. p-Hydroxyphenylacetic acid, which is formed in 67% yield, is isolated from the extract by conventional means.

後処理

  1. temperatureis heated
  2. temperaturecooled
  3. extractionextracted with methyl isobutyl ketone

出典と根拠

ORDレコード
ord-e5a7f46740e04d07bec40324c7d375f1
出典データセット
uspto-grants-1980_04
特許番号
US04198526

関連ノート

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