Pyridine → m-Phenoxybenzyl alpha-isopropyl-4-trifluoromethoxyphenylacetate

HRID 2050088ノート

反応式

HRID 2050088 の反応式
[O:1]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[CH:22]([CH:25]([C:29]1[CH:34]=[CH:33][C:32]([O:35][C:36]([F:39])([F:38])[F:37])=[CH:31][CH:30]=1)[C:26](Cl)=[O:27])([CH3:24])[CH3:23]>C(Cl)Cl>[CH:22]([CH:25]([C:29]1[CH:34]=[CH:33][C:32]([O:35][C:36]([F:37])([F:38])[F:39])=[CH:31][CH:30]=1)[C:26]([O:12][CH2:11][C:10]1[CH:13]=[CH:14][CH:15]=[C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:9]=1)=[O:27])([CH3:24])[CH3:23]

参加物

5

反応物 3

HCID 1049PyridineHCID 262953-Phenoxybenzyl alcoholHCID 20343288HCID 20343288、化合物

生成物 1

HCID 20343285m-Phenoxybenzyl alpha-isopropyl-4-trifluoromethoxyphenylacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of m-phenoxybenzyl alcohol (1.89 g) and pyridine (1 ml) in methylene chloride (6 ml) is added a methylene chloride (7 ml) solution of α-isopropyl-4-trifluoromethoxyphenylacetyl chloride, prepared from the corresponding acid (2.46 g) as illustrated in Example 15. After stirring the reaction mixture overnight, it is washed with water, dilute hydrochloric acid solution, dilute potassium hydroxide solution, water and evaporated to an orange oil. Purification by silica gel chromatography gives the desired ester (2.76 g).

後処理

  1. washis washed with water, dilute hydrochloric acid solution, dilute potassium hydroxide solution, water
  2. customevaporated to an orange oil
  3. customPurification by silica gel chromatography

出典と根拠

ORDレコード
ord-db7261bb0919436a9fe4ad734e5c6cfb
出典データセット
uspto-grants-1980_04
特許番号
US04199595

反応ノート

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