Hydrochloric Acid → HCID 20342248、化合物

HRID 2050195ノート

反応式

HRID 2050195 の反応式
[C:1]1([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]2[CH2:11][CH2:10][CH:9]2[CH:12]=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[C-:21]#[N:22].[K+]>O1CCCC1.O>[OH:13][CH:12]([CH:9]1[CH2:10][CH2:11][N:8]1[CH:7]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:21]#[N:22]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 9032Potassium CyanideHCID 127171451-(Diphenylmethyl)-2-azetidinecarboxaldehyde

生成物 1

HCID 20342248HCID 20342248、化合物収率 103.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1.4 g (5.57 mmoles) of 1-diphenylmethyl-2-formylazetidine in a mixture of 7.5 ml of tetrahydrofuran and 7.5 ml of water is added 0.91 ml (11.14 mmoles) of concentrated hydrochloric acid under cooling and then 0.724 g (11.14 mmoles) of potassium cyanide is added thereto. The mixture is stirred for 2 hours and extracted with 30 ml of ether. The aqueous layer is reextracted with 30 ml of ether. The extract and the above organic layer are combined, washed with water, dried over magnesium sulfate and evaporated under reduced pressure to yield 1.6 g of crude syrupy 2-hydroxy-2-(1-diphenylmethylazetidin-2-yl)acetonitrile in quantitative yield.

後処理

  1. temperatureunder cooling
  2. extractionextracted with 30 ml of ether
  3. extractionThe extract
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-3eb79a8d1808445b9cea4af14a66eb6d
出典データセット
uspto-grants-1980_04
特許番号
US04200628

反応ノート

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