Chloroform → Ethyl 2,6-difluorobenzene-1-carboximidate
反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH2:6])=[O:5].[B-](F)(F)(F)F.[CH3:17][CH2:18][O+](CC)CC.C(Cl)(Cl)Cl>C(Cl)Cl>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4](=[NH:6])[O:5][CH2:17][CH3:18]参加物
5
実験手順
2,6-Difluorobenzamide (1.56 g) in methylene chloride was added to triethyloxonium fluoborate (1.9 g) in methylene chloride and the mixture stirred for 24 hours. The solution was then washed three times with cold sodium carbonate solution and dried over sodium sulphate. The methylene chloride solution was evaporated to yield an oil. This was mixed with chloroform and the solution filtered from insoluble material. Evaporation of the chloroform gave the ethyl 2,6-difluorobenzimidate as a mobile oil.
後処理
- washThe solution was then washed three times with cold sodium carbonate solution
- dry with materialdried over sodium sulphate
- customThe methylene chloride solution was evaporated
- customto yield an oil
- filtrationthe solution filtered from insoluble material
- customEvaporation of the chloroform
出典と根拠
- ORDレコード
- ord-72431eb1f88f400994e63823c8b9c124
- 出典データセット
- uspto-grants-1980_04
- 特許番号
- US04200653
反応ノート
読み込み中…