Isopropanol → 4-Chloro-alpha-(2-fluorophenyl)benzenemethanol

HRID 2050287ノート

反応式

HRID 2050287 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])=[O:9])=[CH:4][CH:3]=1.CC(O)C.[BH4-].[Na+]>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])[OH:9])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 3776IsopropanolHCID 4311764Sodium borohydrideHCID 43160405(4-Chlorophenyl)(2-fluorophenyl)methanone

生成物 1

HCID 205062634-Chloro-alpha-(2-fluorophenyl)benzenemethanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

To a stirred and refluxing mixture of 23.4 parts of (4-chlorophenyl) (2-fluorophenyl)methanone in 280 parts of 2-propanol are added portionwise 3.7 parts of sodium borohydride. Upon completion, stirring is continued for 2 hours at reflux temperature (±80° C.). The reaction mixture is cooled and decomposed by the addition of water. The 2-propanol is evaporated and the residual product is extracted with trichloromethane. The extract is dried, filtered and evaporated, yielding 4-chloro-α-(2-fluorophenyl)benzenemethanol as a residue.

後処理

  1. temperaturerefluxing
  2. stirringUpon completion, stirring
  3. temperatureThe reaction mixture is cooled
  4. customThe 2-propanol is evaporated
  5. extractionthe residual product is extracted with trichloromethane
  6. customThe extract is dried
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-d24239775d374170878c400b79fbd949
出典データセット
uspto-grants-1980_04
特許番号
US04200641

反応ノート

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