Trifluoroacetic acid → cis-3-Amino-2-azidomethyl-4-oxoazetidine

HRID 2050388

反応式

HRID 2050388 の反応式
[N:1]([CH2:4][C@H:5]1[C@@H:8]([NH:9]C(OC(C)(C)C)=O)[C:7](=[O:17])[NH:6]1)=[N+:2]=[N-:3].FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:9][C@H:8]1[C:7](=[O:17])[NH:6][C@H:5]1[CH2:4][N:1]=[N+:2]=[N-:3]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86734331cis-2-Azidomethyl-3-t-butoxycarbonylamino-4-oxoazetidine

生成物 1

HCID 86734332cis-3-Amino-2-azidomethyl-4-oxoazetidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

cis-2-Azidomethyl-3-t-butoxycarbonylamino-4-oxoazetidine (ca. 1 g) is dissolved in 2 ml of methylene chloride and the solution is cooled to 0° and treated with 0.5 ml of trifluoroacetic acid for 30 minutes at 0°. The solution is washed with 5% aqueous sodium bicarbonate and extracted with dilute hydrochloric acid. The aqueous phase is neutralized and extracted with ethyl acetate. Evaporation of the solvent gives the title compound.

後処理

  1. temperaturethe solution is cooled to 0°
  2. washThe solution is washed with 5% aqueous sodium bicarbonate
  3. extractionextracted with dilute hydrochloric acid
  4. extractionextracted with ethyl acetate
  5. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-3611998dda704930ba5869cca4bd70f6
出典データセット
uspto-grants-1980_04
特許番号
US04200572

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