Ammonia → 2-Bromoimidazo[1,2-a]pyridine

HRID 2051111ノート

反応式

HRID 2051111 の反応式
P(Br)(Br)([Br:3])=O.O[C:7]1[N:8]=[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]2[CH:15]=1.N>>[Br:3][C:7]1[N:8]=[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]2[CH:15]=1

参加物

4

反応物 3

HCID 222AmmoniaHCID 24613Phosphorus oxybromideHCID 14674030Imidazo[1,2-a]pyridin-2-ol

生成物 1

HCID 124289572-Bromoimidazo[1,2-a]pyridine収率 19.9%

反応条件

温度
90 °C

実験手順

To 44.0 g of melted phosphorus oxybromide, 12.0 g of 2-hydroxyimidazo[1,2-a]pyridine is added at 60°-85° C. and stirred for 3 hours at 90° C. The mixture is poured into 300 ml of ice water, neutralized with aqueous ammonia and then extracted with chloroform. The collected chloroform layer is dried over anhydrous sodium sulfate. Chloroform is distilled off and the residue is purified by silica gel chromatography (eluent: chloroform) to obtain 3.5 g of the title compound as a crystalline solid.

後処理

  1. extractionextracted with chloroform
  2. dry with materialThe collected chloroform layer is dried over anhydrous sodium sulfate
  3. distillationChloroform is distilled off
  4. customthe residue is purified by silica gel chromatography (eluent: chloroform)

出典と根拠

ORDレコード
ord-3b91fc7bc6524740bf49fea0aaeb9b01
出典データセット
uspto-grants-1991_05
特許番号
US05017212

反応ノート

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