Ammonia → 2-Chloroimidazo[1,2-a]pyridine-3-sulfonamide
反応式
[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[S:11](Cl)(=[O:13])=[O:12].[NH3:15]>C(#N)C>[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[S:11]([NH2:15])(=[O:13])=[O:12]参加物
4
実験手順
A solution of 4.6 g of 2-chloroimidazo[1,2-a]pyridine-3-sulfonylchloride in 60 ml of acetonitrile is added to 60 ml of aqueous ammonia under cooling and stirred for 2 hours at room temperature. The reaction solution is distilled under reduced pressure to remove acetonitrile, and the precipitated crystals are collected by filtration and washed with water to give 3.8 g of the title compound. Upon recrystalization from diluted ethanol, it gives colorless needles mp. 175°-177° C.
後処理
- temperatureunder cooling
- distillationThe reaction solution is distilled under reduced pressure
- customto remove acetonitrile
- filtrationthe precipitated crystals are collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-4dd4885d4ac7406bbb2cf3eeec666347
- 出典データセット
- uspto-grants-1991_05
- 特許番号
- US05017212
反応ノート
読み込み中…