HCID 14422542、化合物 → Imidazo[1,5-a]pyridine-3-sulfonamide

HRID 2051131ノート

反応式

HRID 2051131 の反応式
C([NH:5][S:6]([C:9]1[N:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]2=[CH:11][N:10]=1)(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[CH:11]1[N:10]=[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])[N:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=12

参加物

3

反応物 1

HCID 14422542HCID 14422542、化合物

生成物 1

HCID 19832737Imidazo[1,5-a]pyridine-3-sulfonamide収率 77.1%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

N-(t-Butyl)imidazo[1,5-a]pyridine-3-sulfonamide (1.0 g) is dissolved in 20 ml of trifluoroacetic acid and stirred for 14 days at room temperature. The mixture is concentrated under reduced pressure, and ether is added to the residue to precipitate crystals. The crystals are collected by filtration and dried to give 0.60 g of the title compound. mp. 179°-180° C.

後処理

  1. concentrationThe mixture is concentrated under reduced pressure, and ether
  2. additionis added to the residue
  3. customto precipitate crystals
  4. filtrationThe crystals are collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-93a5aa6cf675491eb5055d96c4015b00
出典データセット
uspto-grants-1991_05
特許番号
US05017212

反応ノート

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