Water → 1-Methyl-α-[3-(trifluoromethyl)phenyl]-1H-imidazole-2-methanol
反応式
[BH4-].[Na+].[CH3:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1)=[O:10].O>CO>[CH3:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[CH:12]=1)[OH:10]参加物
5
実験手順
0.6 g of sodium borohydride is added to a solution of 3.6 g of 1-methyl-α-(3-trifluoromethylphenyl) -1H-imidazole-2-methanone in 25 ml of methanol. The mixture is stirred for 30 minutes and 150 ml of water are added. The precipitate obtained is filtered off and washed with water. It is recrystallized from an ethanol/water mixture.
後処理
- customThe precipitate obtained
- filtrationis filtered off
- washwashed with water
- customIt is recrystallized from an ethanol/water mixture
出典と根拠
- ORDレコード
- ord-8c8c3e1d502b46fbbe9426a89420b007
- 出典データセット
- uspto-grants-1991_05
- 特許番号
- US05017596
反応ノート
読み込み中…