p-Toluenesulfonic acid → HCID 19791550、化合物

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[CH:8]=[C:7]([N:13]1[CH2:17][CH2:16][CH2:15]C1)[CH2:6][CH2:5]2.C(N)(=[O:21])C=C.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:1][C:2]1[C:11]([Cl:12])=[CH:10][C:9]2[C:8]3[CH2:15][CH2:16][C:17](=[O:21])[NH:13][C:7]=3[CH2:6][CH2:5][C:4]=2[CH:3]=1

参加物

反応物 3

HCID 6101p-Toluenesulfonic acid

HCID 6579Acrylamide

HCID 19833158HCID 19833158、化合物

生成物 1

HCID 19791550HCID 19791550、化合物

実験手順

A melt of 10.1 g (0.038 mol) of 1-(6,7-dichloro-3,4-dihydro-2-naphthyl)pyrrolidine. 5.36 g (0.075 mol) of acrylamide and 0.3 g of p-toluenesulfonic acid is stirred under nitrogen at 100° for 2 hours and at 150° for 2 hours. Recrystallization of the melt cake from ethanol yields 8,9-dichloro-1,4,5,6-tetrahydrobenzo[f]quinolin -3(2H)-one with melting point 260-261°.