Water → cis-Octahydroisoindole

HRID 2051613ノート

反応式

HRID 2051613 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1(=O)[NH:11][C:10](=O)[C@H:9]2[CH2:13][CH2:14][CH2:15][CH2:16][C@@H:8]12.O>C(OCC)C.O1CCCC1>[C@@H:8]12[CH2:7][NH:11][CH2:10][C@@H:9]1[CH2:13][CH2:14][CH2:15][CH2:16]2

参加物

6

反応物 3

HCID 962WaterHCID 6992236cis-HexahydrophthalimideHCID 21226445Aluminium lithium hydride

生成物 1

HCID 10964494cis-Octahydroisoindole

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a slurry of lithium aluminium hydride (17.1 g) in dry diethyl ether (375 ml) under a nitrogen atmosphere, cis-hexahydrophthalimide (23.0 g) in dry tetrahydrofuran (300 ml) was added over a two-hour period. The mixture was refluxed for 2.5 hours, cooled and treated very slowly with excess of water. The precipitate was filtered off and the filtrate was evaporated to yield the title compound as a viscous oil, which was used in the next step without purification.

後処理

  1. temperatureThe mixture was refluxed for 2.5 hours
  2. temperaturecooled
  3. filtrationThe precipitate was filtered off
  4. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-d5fdc02a68d7413188ac41fca4b5cb6f
出典データセット
uspto-grants-1980_01
特許番号
US04181659

反応ノート

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