Urea → HCID 20379521、化合物
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:9]2[C:10]([NH2:15])=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:2]=1.N[C:17](N)=[O:18]>ClC(Cl)Cl.CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:8]2[C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[NH:15][C:17]2=[O:18])[CH:2]=1参加物
5
実験手順
A mixture of 25 parts of N-(3-pyridinylmethyl)-1,2-benzenediamine and 11 parts of urea is melted together to 180°-190° C. and the melt is stirred for 30 minutes at this temperature. The reaction mixture is cooled and dissolved in a mixture of trichloromethane and methanol. The solvent is evaporated and the residue is crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 24 parts (86%) of 1,3-dihydro-1-(3-pyridinylmethyl)-2H-benzimidazol-2-one; mp. 160.5° C.
後処理
- customis melted together to 180°-190° C.
- temperatureThe reaction mixture is cooled
- customThe solvent is evaporated
- customthe residue is crystallized from 4-methyl-2-pentanone
- filtrationThe product is filtered off
- customdried
出典と根拠
- ORDレコード
- ord-8b79b2388a694073b45f3af3e5083eea
- 出典データセット
- uspto-grants-1980_01
- 特許番号
- US04181802
反応ノート
読み込み中…