Sodium Hydroxide → Diethyl [6-(4-carboxyphenoxy)hexyl]phosphonate

HRID 2051754ノート

反応式

HRID 2051754 の反応式
[OH-].[Na+].[C:3]([C:8]1[CH:28]=[CH:27][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][P:19](=[O:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])=[CH:10][CH:9]=1)([O:5]CC)=[O:4]>C(O)C>[C:3]([C:8]1[CH:9]=[CH:10][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][P:19](=[O:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])=[CH:27][CH:28]=1)([OH:5])=[O:4]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 5271409Benzoic acid, 4-((6-(diethoxyphosphinyl)hexyl)oxy)-, ethyl ester

生成物 1

HCID 5271411Diethyl [6-(4-carboxyphenoxy)hexyl]phosphonate収率 90.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution (21 ml) of 1N sodium hydroxide in ethanol was added to a solution of 8.3 g of diethyl [6-(4-carbethoxyphenoxy)hexyl]phosphonate (Example 8) in 20 ml of ethanol. The reaction mixture was stirred at room temperature for two days. The solid fraction was collected, digested with 100 ml of ether, filtered and dried to give 7.0 g of diethyl [6-(4-carboxyphenoxy)hexyl]phosphonate in the form of its sodium salt, m.p. 215°-216° C.

後処理

  1. customThe solid fraction was collected
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-e1086161db3d4d7494d7ca12ff7fbd34
出典データセット
uspto-grants-1980_01
特許番号
US04182759

反応ノート

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