Methyl iodide → HCID 20377886、化合物

HRID 2052419ノート

反応式

HRID 2052419 の反応式
Cl.[F:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:8])=[CH:5][CH:4]=1.[CH3:19][I:20]>CC(C)=O>[CH3:19][I:20].[F:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:8])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 20377895(Pyridin-3-yl)methyl 4-fluorobenzoate--hydrogen chloride (1/1)

生成物 1

HCID 20377886HCID 20377886、化合物収率 60%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
0 °C

実験手順

4.4 g. of 3-[(4-fluorobenzoyl)-oxymethyl]-pyridine hydrochloride prepared according to Example 1 (a) are dissolved in 40 ml. of acetone and 3 g. of methyl iodide are added thereto. The reaction mixture is refluxed for 30 minutes and then cooled to 0° C. The precipitated quaternary salt is separated by filtration and recrystallized from 100 ml. of anhydrous ethanol. 4.2 g. of 3-[(4-fluorobenzoyl)-oxymethyl]-pyridine methyliodide (60% of theoretical yield) are obtained; m.p.: 132°-133° C.

後処理

  1. dissolutionare dissolved in 40 ml
  2. temperatureThe reaction mixture is refluxed for 30 minutes
  3. customThe precipitated quaternary salt is separated by filtration
  4. customrecrystallized from 100 ml

出典と根拠

ORDレコード
ord-03a26ac6a7954575958f0883efb484e1
出典データセット
uspto-grants-1980_01
特許番号
US04184040

反応ノート

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