Chlorosuccinimide → HCID 20351119、化合物

HRID 2052571ノート

反応式

HRID 2052571 の反応式
[CH3:1][S:2][CH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[NH:5][C:4]1=[O:15].[Cl:16]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Cl:16][C:3]1([S:2][CH3:1])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[NH:5][C:4]1=[O:15]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 3266503-Methylthio-5-nitrooxindole

生成物 1

HCID 20351119HCID 20351119、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 3-methylthio-5-nitrooxindole (900 mg, 4 mmol) and N-chlorosuccinimide (600 mg, 4.5 mmol) in 50 ml of chloroform was stirred at room temperature for 1 hour and then evaporated to dryness in vacuo, yielding 3-chloro-3-methylthio-5-nitrooxindole. The residue was dissolved in 15 ml of tetrahydrofuran and added to a vigorously stirred slurry of red mercuric oxide powder (900 mg, 4.3 mmol) and boron trifluoride etherate (600 mg, 4.3 mmol) in 100 ml of 20 percent aqueous tetrahydrofuran. After stirring at room temperature for two hours, the reaction mixture was extracted with three 100-ml portions of chloroform. The chloroform layer was dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was recrystallized from 95 percent ethanol to give 5-nitroisatin (600 mg, 78%), mp 252°-254°

後処理

  1. customevaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-a6c32b1252c6452695737de16ebcfd2b
出典データセット
uspto-grants-1980_01
特許番号
US04186132

反応ノート

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