5-Fluoroorotic acid monohydrate → 5-Fluorouracil

HRID 2052724ノート

反応式

HRID 2052724 の反応式
O.C(O)(=O)C1NC(=O)NC(=O)C=1.O.[F:14][C:15]1[C:23](=[O:24])[NH:22][C:21](=[O:25])[NH:20][C:16]=1C(O)=O>>[F:14][C:15]1[C:23](=[O:24])[NH:22][C:21](=[O:25])[NH:20][CH:16]=1

参加物

3

反応物 2

HCID 162127495-Fluoroorotic acid monohydrateHCID 162185041,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid monohydrate

生成物 1

HCID 33855-Fluorouracil

反応条件

温度
260 °C

実験手順

In the reaction, the conversion of the orotic acid monohydrate was 100% and the yield of 5-fluoro-orotic acid monohydrate was 85.0%. The crystals were heated at 260° C. under a reduced pressure of lower than 1 mmHg to perform the decarboxylation to obtain 22.5 g of 5-fluorouracil.

後処理

  1. customIn the reaction

出典と根拠

ORDレコード
ord-efbca071b4d343cf9aff19e00611d2dd
出典データセット
uspto-grants-1980_01
特許番号
US04186266

反応ノート

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