Acetic Acid → HCID 69309751、化合物

HRID 2053948ノート

反応式

HRID 2053948 の反応式
F[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].O.[NH2:16][NH2:17].C(O)(=O)C>CS(C)=O>[NH:16]([C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12])[NH2:17]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 24654Hydrazine hydrate (1:1)HCID 5222684-Fluoro-3-(trifluoromethyl)benzoic acid

生成物 1

HCID 69309751HCID 69309751、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
100 °C

実験手順

7.5 g (36 mmol) of 4-fluoro-3-trifluoromethylbenzoic acid is dissolved in 12 mL dimethylsulfoxide and, after the addition of 15 mL (0.24 mol) of hydrazine hydrate (80%), stirred for 5 hours at 100° C. After cooling, it is combined with ice and acidified with glacial acetic acid. The precipitated product is suction filtered and dried. Yield: 5.3 g (66%).

後処理

  1. temperatureAfter cooling
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-aaa65e6afa094205919d644300514b23
出典データセット
uspto-grants-2008_02
特許番号
US07326791B2

反応ノート

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