Sodium Hydroxide → 4-(4-Oxo-2-propyl-4,5-dihydroimidazo[4,5-c]pyridin-1-yl)-3-trifluoromethylbenzoic acid

HRID 2054061ノート

反応式

HRID 2054061 の反応式
[O:1]=[C:2]1[C:7]2[N:8]=[C:9]([CH2:23][CH2:24][CH3:25])[N:10]([C:11]3[CH:18]=[CH:17][C:14]([C:15]#N)=[CH:13][C:12]=3[C:19]([F:22])([F:21])[F:20])[C:6]=2[CH:5]=[CH:4][NH:3]1.[OH-:26].[Na+].ClCCl.C[OH:32]>C(O)C>[O:1]=[C:2]1[C:7]2[N:8]=[C:9]([CH2:23][CH2:24][CH3:25])[N:10]([C:11]3[CH:18]=[CH:17][C:14]([C:15]([OH:32])=[O:26])=[CH:13][C:12]=3[C:19]([F:20])([F:21])[F:22])[C:6]=2[CH:5]=[CH:4][NH:3]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 21226129Dichloromethane methanolHCID 693113534-(4-Oxo-2-propyl-4,5-dihydroimidazo[4,5-c]-pyridin-1-yl)-3-trifluoromethylbenzonitrile

生成物 1

HCID 693125974-(4-Oxo-2-propyl-4,5-dihydroimidazo[4,5-c]pyridin-1-yl)-3-trifluoromethylbenzoic acid収率 98%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Prepared analogously to Example 1f from 4-(4-oxo-2-propyl-4,5-dihydroimidazo[4,5-c]-pyridin-1-yl)-3-trifluoromethylbenzonitrile and sodium hydroxide solution in ethanol. Yield: 98%; Rf value: 0.42 (silica gel: dichloromethane/methanol/glacial acetic acid=4:1:0.1).

出典と根拠

ORDレコード
ord-2a6944a944a243689b0274c268cd396d
出典データセット
uspto-grants-2008_02
特許番号
US07326791B2

反応ノート

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