関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | Cyclodecanone | HCID 73918 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | Azacycloundecan-2-one | HCID 70523 | 112.1% |
反応手順
Cyclodecanone (n=6) (1.0 g) in 10 mL concentrated sulfuric acid was cooled to 0° C. and 0.54 g of sodium azide was added. The reaction continued to stir at 0° C. for 1 h and warmed to room temperature where it was stirred for two h. The solution was diluted with cold water and treated with cold 10% NaOH solution until pH=9. Extraction with ether (2×), drying over magnesium sulfate and evaporation of solvent provided 1.23 g of 2-azacycloundecanone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07329683B2 |
|---|
| 出典データセット | uspto-grants-2008_02 |
|---|
| ORD ID | ord-b94c6932bf0b45b18cd81454ddf177d6 |
|---|
| 出典メモ | uspto-grants-2008_02 |
|---|
