化工社化工社 化学情報印刷レポート · 研究参考用
Azacycloundecan-2-one → 2-Methoxyazacyclododec-1-ene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Azacycloundecan-2-one | HCID 70523 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) | HCID 2735153 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Methoxyazacyclododec-1-ene | HCID 12957742 | — |
反応手順
2-Azacycloundecanone (0.87 g) was dissolved in 20 mL methylene chloride and stirred at room temperature under nitrogen. 1.5 g Trimethyloxonium tetrafluoroborate was added and the reaction stirred overnight. The mixture was added to saturated aqueous sodium bicarbonate and extracted with methylene chloride (2×). The combined organic layers were washed with brine, dried over magnesium sulfate, and the solvent evaporated to provide crude 2-methoxyazacyclododec-1-ene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07329683B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-ebd9a9e795624384900e488e399f1f20 |
| 出典メモ | uspto-grants-2008_02 |