反应详情

2-Azacycloundecanone (0.87 g) was dissolved in 20 mL methylene chloride and stirred at room temperature under nitrogen. 1.5 g Trimethyloxonium tetrafluoroborate was added and the reaction stirred overnight. The mixture was added to saturated aqueous sodium bicarbonate and extracted with methylene chloride (2×). The combined organic layers were washed with brine, dried over magnesium sulfate, and the solvent evaporated to provide crude 2-methoxyazacyclododec-1-ene.

1. stirringthe reaction stirred overnight
2. extractionextracted with methylene chloride (2×)
3. washThe combined organic layers were washed with brine
4. dry with materialdried over magnesium sulfate
5. customthe solvent evaporated