Hydrochloric Acid → {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride

HRID 2054693

反応式

HRID 2054693 の反応式
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1>CC(C)=O.CCOCC>[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 9885359{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone

生成物 1

HCID 131726767{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 3283Diethyl Ether溶媒

実験手順

For salt formation, 1N hydrochloric acid is added to a solution of {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone in 60 ml of acetone and 50 ml of ether until crystals form. When crystallisation is complete, the mother liquor is filtered off, and the precipitate is washed with ether and dried, giving {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride, m.p. 238-240°.

後処理

  1. customform
  2. customWhen crystallisation
  3. filtrationthe mother liquor is filtered off
  4. washthe precipitate is washed with ether
  5. customdried

出典と根拠

ORDレコード
ord-d0a23f68871b41f4a282286bf96a4ab9
出典データセット
uspto-grants-2008_02
特許番号
US07329749B2

関連ノート

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