Ethyl Acetate → 5-Nitroquinoline-2-carbaldehyde

HRID 2054976ノート

反応式

HRID 2054976 の反応式
I([O-])(=O)(=O)=O.[Na+].OC([N:11]1[C:20]2[C:15](=[C:16]([N+:21]([O-:23])=[O:22])[CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH2:12]1)CO.[C:24](OCC)(=[O:26])C>O1CCCC1.O>[N+:21]([C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:15]=1[CH:14]=[CH:13][C:12]([CH:24]=[O:26])=[N:11]2)([O-:23])=[O:22]

参加物

6

反応物 3

HCID 8857Ethyl AcetateHCID 21948859HCID 21948859、化合物HCID 23667635Sodium periodate

生成物 1

HCID 47370745-Nitroquinoline-2-carbaldehyde

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2.99 g (14.0 mmol) of sodium periodate is added to a solution that consists of 1.64 g (7.0 mmol) of 1-(1,2-dihydroxyethyl)-5-nitroquinoline in 42 ml of tetrahydrofuran and 7.0 ml of water. After 20 hours at room temperature, ethyl acetate is added, and the organic phase is washed with saturated sodium chloride solution. After the organic phase is dried on sodium sulfate, after the solvent is removed, and after purification on silica gel with hexane-ethyl acetate (0-100%), 1.40 g (99% of theory) of the product is obtained.

後処理

  1. washthe organic phase is washed with saturated sodium chloride solution
  2. customAfter the organic phase is dried on sodium sulfate
  3. customafter the solvent is removed
  4. customafter purification on silica gel with hexane-ethyl acetate (0-100%), 1.40 g (99% of theory) of the product
  5. customis obtained

出典と根拠

ORDレコード
ord-b79ca8c747c042d0b04597976a8a969f
出典データセット
uspto-grants-2008_02
特許番号
US07329753B2

反応ノート

読み込み中…