反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[S:10](Cl)(=[O:12])=[O:11].S([O-])([O-])=O.[Na+].[Na+].[C:20](=O)(O)[O-].[Na+].BrCC(O)=O>O>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[S:10]([CH3:20])(=[O:12])=[O:11]参加物
6
反応条件
- 温度
- 150 °C
実験手順
2-Chloro-4,5-difluorobenzenesulfonyl chloride (300 mg) was added to a solution of sodium sulfite (306 mg) and sodium bicarbonate (153 mg) in water (4 mL). The mixture was heated to 150° C. in a sealed microwave vial for 400 seconds and allowed to cool. The mixture was treated with bromoacetic acid (253 mg) in water (1 mL), and heated to 150° C. for 300 seconds then allowed to cool, following which the precipitate was removed by filtration and dried in vacuo to give the desired compound (132 mg). The material was used without further purification.
後処理
- temperatureto cool
- temperatureheated to 150° C. for 300 seconds
- temperatureto cool
- customwas removed by filtration
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-b692961d75f642889f4ac786d8c9eff8
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745475B2
関連ノート
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