Sodium Hydroxide → 3-(Pyridin-4-yl)butanoic acid
反応式
[OH-].[Na+].[CH3:3][CH:4]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[CH2:5][C:6]([O:8]CC)=[O:7]>CO.O>[CH3:3][CH:4]([C:11]1[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=1)[CH2:5][C:6]([OH:8])=[O:7]参加物
5
実験手順
Sodium hydroxide (0.19 g, 4.8 mmol) was added to a solution of ethyl 3-methyl-3-pyridin-4-ylpropanoate (Method 8; 0.501 g, 2.6 mmol) in MeOH (10 ml) and water (5 ml). The mixture was stirred at room temperature for 18 hours. The solvent was removed in vacuc and the residue shaken with 1 M hydrochloric acid (4.8 ml). The solvent was removed in vacuo to leave a colourless solid. M/z′164 (M-H)−.
後処理
- customThe solvent was removed in vacuc
- stirringthe residue shaken with 1 M hydrochloric acid (4.8 ml)
- customThe solvent was removed in vacuo
- customto leave a colourless solid
出典と根拠
- ORDレコード
- ord-5a041dda89f346ea97fe44f785edbc6d
- 出典データセット
- uspto-grants-2008_02
- 特許番号
- US07332492B2
反応ノート
読み込み中…