Hydrochloric Acid → 2-(Piperidin-3-YL)acetonitrile
反応式
C(OC([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([CH2:17][C:18]#[N:19])[CH2:12]1)=O)C1C=CC=CC=1.Cl>C(O)C.[Pd]>[C:18]([CH2:17][CH:13]1[CH2:14][CH2:15][CH2:16][NH:11][CH2:12]1)#[N:19]参加物
5
実験手順
1-Benzyloxycarbonyl-3-cyanomethylpiperidine (Method 22; 12.5 g) was dissolved in ethanol (20 ml) and ethereal HCl (1 ml) and 5% palladium on charcoal (2.0 g) was added. The mixture was shaken under an atmosphere of hydrogen for 2.5 hours. The catalyst was filtered and the filtrate evaporated in vacuo. The crude product was dissolved in ethanol and recrystallized from ether. M/z 124 [M+].
後処理
- filtrationThe catalyst was filtered
- customthe filtrate evaporated in vacuo
- dissolutionThe crude product was dissolved in ethanol
- customrecrystallized from ether
出典と根拠
- ORDレコード
- ord-d5fd5cdc22d24deba6230bbff09eae6d
- 出典データセット
- uspto-grants-2008_02
- 特許番号
- US07332492B2
反応ノート
読み込み中…