Dimethylformamide → 2-Ethoxybenzoyl chloride
反応式
[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9](CCCCCCCCCCCCCCC)[C:5]=1[C:6](O)=[O:7])[CH3:2].S(Cl)([Cl:30])=O.CN(C)C=O>CCCCCC>[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([Cl:30])=[O:7])[CH3:2]参加物
5
実験手順
To a stirred solution of 2-Ethoxy-6-pentadecylbenzoic Acid (6.5 g, 16 mmol) in hexane (60 mL) were added thionyl chloride (2.5 g, 21 mmol) and N,N-dimethylformamide (0.5 mL). The reaction mixture was heated to reflux for 1 h. After the reaction was complete, the solvent was evaporated under reduced pressure to yield the desired 2-Ethoxy-benzoyl Chloride, which was redissolved in dichloromethane (50 mL) and used for the condensation with anilides.
後処理
- temperatureThe reaction mixture was heated
- temperatureto reflux for 1 h
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-0820ff048c7a4a50846507374d525843
- 出典データセット
- uspto-grants-2008_02
- 特許番号
- US07332629B2
反応ノート
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