1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 135610070、化合物

HRID 2056268ノート

反応式

HRID 2056268 の反応式
[C:1]([C:4]1[O:8][N:7]=[C:6]([O:9][CH2:10][C:11]([O:13]CC)=[O:12])[CH:5]=1)(O)=O.CCN=C=NCCCN(C)C.[CH2:27]([N:30]1[C:37]([NH2:38])=[C:36]([NH2:39])[C:34](=[O:35])[N:33]([CH2:40][CH2:41][CH3:42])[C:31]1=[O:32])[CH2:28][CH3:29]>CO>[CH2:40]([N:33]1[C:34](=[O:35])[C:36]2[NH:39][C:1]([C:4]3[O:8][N:7]=[C:6]([O:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=3)=[N:38][C:37]=2[N:30]([CH2:27][CH2:28][CH3:29])[C:31]1=[O:32])[CH2:41][CH3:42]

参加物

5

反応物 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedioneHCID 58846560HCID 58846560、化合物

生成物 1

HCID 135610070HCID 135610070、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of ethyl (5-carboxyisoxazol-3-yl)oxyacetate (0.5 mmol) and EDCI (0.5 mmol) in methanol (20 mL) was added a solution of 1,3-dipropyl-5,6-diaminouracil (0.5 mmol), dissolved in methanol (20 mL). The mixture was stirred at room temperature for two hours, the solvent was then removed in vacuo, water added, and the solid that formed was collected by filtration and washed with additional cold water. The intermediate amide was heated in 20 mL of 2.5 N NaOH at 70° C. for 30 minutes to afford the desired 2-[5-(1,3-dipropyl-xanthin-8-yl)-isoxazol-3-yloxy]acetic acid.

後処理

  1. customthe solvent was then removed in vacuo, water
  2. additionadded
  3. customthe solid that formed
  4. filtrationwas collected by filtration
  5. washwashed with additional cold water
  6. temperatureThe intermediate amide was heated in 20 mL of 2.5 N NaOH at 70° C. for 30 minutes

出典と根拠

ORDレコード
ord-f404d52827924dd3a81d0a51ce07c851
出典データセット
uspto-grants-2008_02
特許番号
US07335655B2

反応ノート

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