Piperidine → HCID 11569170、化合物

DIPEA (0.36 mL, 1.95 mmol) was added to a suspension of 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(1-methyl-1H-pyrazol-3-yl)amino]carbonyl}phenoxy)benzoic acid (200 mg, 0.49 mmol), HATU (390 mg, 1.02 mmol) and piperidine (0.19 mL, 1.95 mmol) in DMF (3 mL) and the mixture stirred at, ambient temperature for 24 hours. The solvent was evaporated. Water (30 mL) was added and the mixture extracted with ethyl acetate (3×15 mL). The combined organic extracts were washed with brine (30 mL), dried, (MgSO4), and evaporated to a residue which was chromatographed on silica, eluting with a gradient of 0-20% methanol in ethyl acetate, to give the desired compound (167 mg).

1. customThe solvent was evaporated
2. additionWater (30 mL) was added
3. extractionthe mixture extracted with ethyl acetate (3×15 mL)
4. washThe combined organic extracts were washed with brine (30 mL)
5. dry with materialdried, (MgSO4),
6. customevaporated to a residue which
7. customwas chromatographed on silica
8. washeluting with a gradient of 0-20% methanol in ethyl acetate

ORDレコード

ord-25a3926d96164bfebece30f1aa4f3196

出典データセット

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07745475B2