Tetrahydrofuran → Ethyl (5-chloro-1,3-dihydro-2-benzofuran-1-yl)acetate

HRID 2056745ノート

反応式

HRID 2056745 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[CH:6](O)[O:7][CH2:8][C:4]=2[CH:3]=1.C(=O)([O-])[O-:13].[Cs+].[Cs+].[CH2:18]1[CH2:22][O:21][CH2:20][CH2:19]1>>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[CH:6]([CH2:19][C:20]([O:21][CH2:22][CH3:18])=[O:13])[O:7][CH2:8][C:4]=2[CH:3]=1

参加物

4

反応物 3

HCID 8028TetrahydrofuranHCID 10796Cesium carbonateHCID 693101565-Chloro-1,3-dihydroisobenzofuran-1-ol

生成物 1

HCID 86592978Ethyl (5-chloro-1,3-dihydro-2-benzofuran-1-yl)acetate

反応条件

温度
0 °C

実験手順

5-Chloro-1,3-dihydro-2-benzofuran-1-ol (2.95 g, 17.3 mmol) was dissolved in THF (60 mL) and cooled to 0° C. Triethyl phosphonoacetate (11.7 g, 52.1 mmol) and caesium carbonate (17 g, 52.1 mmol) were added. After 20 min the cold bath was removed and the reaction mixture allowed to stir at room temperature for 3 h, then quenched with a saturated solution of ammonium chloride and extracted with ethyl acetate. The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated in vacuo. Purification by column chromatography, eluting with ethyl acetate/hexane (1:4), yielded the title compound as a colourless oil.

後処理

  1. customAfter 20 min the cold bath was removed
  2. customquenched with a saturated solution of ammonium chloride
  3. extractionextracted with ethyl acetate
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. customevaporated in vacuo
  8. customPurification by column chromatography
  9. washeluting with ethyl acetate/hexane (1:4)

出典と根拠

ORDレコード
ord-27d79bba010c479c936a965ddb4a889c
出典データセット
uspto-grants-2008_02
特許番号
US07335660B2

反応ノート

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