Phosgene → 3-Chloro-5-isocyanatoisoquinoline

HRID 2056883

反応式

HRID 2056883 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([Cl:12])[N:6]=[CH:7]2.[C:13](Cl)(Cl)=[O:14]>C1(C)C=CC=CC=1.C(N(CC)CC)C>[Cl:12][C:5]1[N:6]=[CH:7][C:8]2[C:3]([CH:4]=1)=[C:2]([N:1]=[C:13]=[O:14])[CH:11]=[CH:10][CH:9]=2

参加物

5

反応物 2

HCID 6371PhosgeneHCID 167490403-Chloroisoquinolin-5-amine

生成物 1

HCID 223376853-Chloro-5-isocyanatoisoquinoline

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒2 回HCID 8471Triethylamine溶媒

実験手順

5-Amino-3-chloroisoquinoline (740 mg, 4.15 mmol) was suspended in toluene (20 mL) and treated with 20% w/v phosgene solution in toluene (9 mL) and triethylamine (5 mL). The mixture was refluxed overnight and was then concentrated in vacuo and used in the next step without further purification.

後処理

  1. temperatureThe mixture was refluxed overnight
  2. concentrationwas then concentrated in vacuo
  3. customused in the next step without further purification

出典と根拠

ORDレコード
ord-a82578d1d6af41c8ba2a0bc2a685a9d5
出典データセット
uspto-grants-2008_02
特許番号
US07335678B2

関連ノート

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