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Phosgene → 3-Chloro-5-isocyanatoisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | 3-Chloroisoquinolin-5-amine | HCID 16749040 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 3-Chloro-5-isocyanatoisoquinoline | HCID 22337685 | — |
反応手順
5-Amino-3-chloroisoquinoline (740 mg, 4.15 mmol) was suspended in toluene (20 mL) and treated with 20% w/v phosgene solution in toluene (9 mL) and triethylamine (5 mL). The mixture was refluxed overnight and was then concentrated in vacuo and used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07335678B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-a82578d1d6af41c8ba2a0bc2a685a9d5 |
| 出典メモ | uspto-grants-2008_02 |