反应详情

5-Amino-3-chloroisoquinoline (740 mg, 4.15 mmol) was suspended in toluene (20 mL) and treated with 20% w/v phosgene solution in toluene (9 mL) and triethylamine (5 mL). The mixture was refluxed overnight and was then concentrated in vacuo and used in the next step without further purification.

1. temperatureThe mixture was refluxed overnight
2. concentrationwas then concentrated in vacuo
3. customused in the next step without further purification